Rheumatoid factor plaque-forming cells in rheumatoid synovial tissue.
Clin Exp Immunol, 1977/5;28(2):197-203.
Taylor-Upsahl MM, Abrahamsen TG, Natvig JB
PMID: 326444
Impact factor: 5.732
Abstract
Cells producing rheumatoid factor (RF) were readily detected in vitro by means of a haemolytic plaque assay system employing sheep erythrocytes (SRBC) sensitized with reduced and alkylated rabbit IgG anti-SRBC antibody as target cells. Rheumatoid factor-producing, plaque-forming cells (RF-PFC) were observed in all of the synovial tissue cell preparations from seropositive rheumatoid arthritis patients studied. The numbers of RF-PFC varied considerably without any direct correlation with serum titres of RF antibody activity. However, high numbers of RF-PFC were never found in patients with low rheumatoid factor titres whereas, high and low numbers of RF-PFC were found among the patients with high RF titres. Synovial tissue cell preparations from a group of seronegative patients, with only one exception, failed to exhibit RF-PFC.
MeSH terms
Adolescent; Adult; Aged; Antibody-Producing Cells; Arthritis, Rheumatoid; Cell Count; Child; Erythrocytes; Female; Hemolytic Plaque Technique; Humans; Immunoglobulin G; Male; Middle Aged; Rheumatoid Factor; Synovial Membrane
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