Synthesis and in vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin.
J Asian Nat Prod Res, 2021/7;23(7):703-711.
Huang XL[1], Chen JL[1], Li XL[1], Zhao L[1], Cui YD[1], Liu JY[1], Morris-Natschke SL[2], Masuo G[2], Cheng YY[2], Lee KH[2, 3], Chen DF[4], Zhang J[1]
Affiliations
PMID: 32441118DOI: 10.1080/10286020.2020.1760851
Impact factor: 1.61
Abstract
Fourteen glaucocalyxin A biotinylated derivatives, one glaucocalyxin C biotinylated derivative, and two oridonin biotinylated derivatives were designed and synthesized. Their structures were confirmed from 1H NMR, 13C NMR and HRMS data. The derivatives were evaluated for cytotoxic activities against lung (A549), cervical cancer cell line HeLa derivative (KB), multidrug-resistant KB subline (KB-VIN), triple-negative breast (MDA-MB-231), and estrogen receptor-positive breast (MCF-7) cancer cell lines.[Formula: see text].
Keywords: Glaucocalyxin A; anticancer activity; biotin; glaucocalyxin C; oridonin
MeSH terms
Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diterpenes, Kaurane; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Molecular Structure; Structure-Activity Relationship
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