Effect of ethidium bromide on growth and morphology of Leishmania tarentolae promastigotes in vitro.
Acta Trop, 1978/9;35(3):239-46.
PMID: 31777
Impact factor: 3.222
Abstract
Incubation of Leishmania tarentolae promastigotes in 0.01 microgram/ml ethidium bromide in Neo Ye medium for 96 h resulted in 60% inhibition of cell growth and 91% dyskinetoplasty. After 48 h incubation in ethidium bromide over 50% of the cells were scored dyskinetoplastic by light microscopy although the electron microscopical examination revealed that most promastigotes contained at least a small amount of kDNA. A few of the treated cells undergoing division contained two kinetoplasts--one devoid of kDNA and the other with a reduced amount of kDNA as seen in the electron micrographs.
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