[Physiopathology of rheumatoid psoriasis].
Rev Rhum Mal Osteoartic, 1979/10;46(10):551-60.
Sany J, Clot J, Seignalet J, Guilhou JJ, Serre H
PMID: 317533
Abstract
The physiopathology of rhumatoid psoriasis (RP) is poorly known. Besides the genetic factors we study immunological disorders from a series of 51 cases. We found mainly an increase of serum IgA, a decrease of IgM, a low level of circulating immune complexes, sometimes IgG type antiglobulin factor (very seldom IgM type, which explains the sero-negativity) seldom antinuclear antibodies; we found also a diminution of T lymphocytes detected by a decrease of E rosette - forming cells and an increase of the lymphocyte subpopulation forming high avidity EA rosettes, whereas the mitogenic response is normal or slightly decreased in the presence of Con A (not significant). A increased frequency of HLA DRW5 and DRW2 was found but too few cases were studied to make possible a definite conclusion. This immunopathologic profile is compared to that of psoriasis with anthropathy. The relevance of immune disorders in the physiopathology of RP is discussed.
MeSH terms
Adolescent; Adult; Aged; Animals; Antibody Formation; Arthritis, Rheumatoid; Cattle; Cell Membrane; Diagnosis, Differential; Female; HLA Antigens; Humans; Immunity, Cellular; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lymphocytes; Male; Middle Aged; Mitogens; Psoriasis; Rosette Formation; T-Lymphocytes
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