Lymphocyte activation by Con A.
Haematologia (Budap), 1978-1979;12(1-4):37-45.
Möller G, Hammarström L, Möller E, Persson U, Smith E, Waterfield D, Waterfield E
PMID: 317062
Abstract
Con A can activate cytotoxic effector cells, helper cells and suppressor cells. In all cases Con A activates polyclonally and thus the entire T cell repertoir can be revealed by Con A activation. Nylon purified T cells cannot be activated by Con A. however, in the presence of helper cells, such as adherent cells, or in the presence of serum from several species, Con A activates purified T cells. The serum factors that are responsible for Con A activation of purified T cells are present in the albumin fraction. It is suggested that Ia molecules may be responsible for the ability of Con A to activate purified T cells and a general hypothesis for T cell activation is outlined.
MeSH terms
Albumins; Animals; Cell Separation; Concanavalin A; Cytotoxicity, Immunologic; H-2 Antigens; Isoantigens; Lipopolysaccharides; Lymphocyte Activation; Mice; Receptors, Antigen, T-Cell; T-Lymphocytes
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