Cross protection among togaviruses in nude mice and littermates.
J Gen Virol, 1979/10;45(1):89-98.
Latif Z, Gates D, Wust CJ, Brown A
PMID: 316446
Impact factor: 5.141
Abstract
After immunization with Sindbis virus, T-cell deficient nude mice, compared to normal littermates, were equally protected against challenge with Sindbis virus. However, the nude mice showed about one-tenth the protection observed with normal littermates after challenge with Semliki Forest virus at a dose of 100 LD50. This consistent with our previous interpretation that sensitized T-cell populations play a major role in cross protection between the two togaviruses. The remaining low level of specific cross protection in nude mice (detectable only at a challenge dose of 10 LD50) could not be attributed to an anamnestic response of neutralizing antibody to the challenge virus or to an effective antibody-dependent, complement-mediated cytolysis of infected cells in vivo. Other possible compensatory mechanisms to explain the low level of specific cross protection in nude mice are discussed.
MeSH terms
Animals; Antibodies, Viral; Arbovirus Infections; Cross Reactions; Cytotoxicity, Immunologic; Immunization; Immunologic Memory; Mice; Mice, Nude; Semliki forest virus; Sindbis Virus; T-Lymphocytes
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