Antipyretic effect of acetaminophen suppositories in rats.
J Pharm Sci, 1979/9;68(9):1105-7.
PMID: 315458
Impact factor: 3.784
Abstract
An animal model used yeast-fevered rats to measure the relative antipyretic effects of different commercially available acetaminophen-containing suppositories. A laboratory-prepared acetaminophen-containing suppository and placebo suppositories also were investigated. Release from the suppositories was measured in vitro. All acetaminophen products containing 600 mg of drug elicited significant decreases in the rectal temperature of fever-induced rats.
MeSH terms
Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Fever; Male; Rats; Rectum; Suppositories; Time Factors; Yeasts
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