Effects of hyperthermia on the mouse testis and its response to X-rays, as assayed by weight loss.
Int J Radiat Biol Relat Stud Phys Chem Med, 1979/6;35(6):521-8.
Hand JW, Walker H, Hornsey S, Field SB
PMID: 314427
Abstract
The effects of both hyperthermia alone and X-rays combined with hyperthermia on mouse testis have been investigated. Testis weight on heating time was observed for temperatures in the range 39.5 to 43.75 degrees C. The relationship between the reaction rate and the reciprocal of absolute temperature indicated that, over the temperature range considered, the activation energy associated with such thermal damage was (646 +/- 45) x 10(3) J mol-1. No evidence was obtained to indicate a change in slope of the Arrhenius plot over this temperature range. Finally, despite the high sensitivity of the testis to heat and X-rays, no thermal enhancement of the weight loss after irradiation was observed when thermal treatments which, if given alone would produce some observable damage, were administered immediately after irradiation.
MeSH terms
Animals; Dose-Response Relationship, Radiation; Hot Temperature; Male; Mice; Organ Size; Testis; Time Factors; X-Rays
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