Protein synthesis and secretion by activated human lymphocytes.
Int Arch Allergy Appl Immunol, 1979;60(1):1-8.
Bresnihan B, Lavalle C, Jasin HE
PMID: 313374
Abstract
Human peripheral blood mononuclear cells showed increased synthesis and secretion of protein in response to stimulation by mitogens. Protein secretion in response to concanavalin A (Con A) correlated with cellular proliferation and originated from the proliferating cells. Selective depletion of either B lymphocytes or monocytes did not lead to a reduction in the total protein secreted, suggesting that the T lymphocyte was the cell contributing most of the synthetic activity. It is concluded that the measurement of newly synthesized and secreted protein by Con A activated mononuclear cells is a measurement of the T-lymphocyte response.
MeSH terms
Agammaglobulinemia; Concanavalin A; DNA; Humans; Kinetics; Lectins; Lymphocyte Activation; Mitomycins; Proteins; T-Lymphocytes
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