Synaptosomal uptake of hypothalamic monoamines and recovery of pituitary-adrenal activity following medial forebrain bundle lesions in rats.
Neuroendocrinology, 1979;28(4):273-80.
Heybach JP, Brown PA, Vernikos-Danellis J
PMID: 312469
Impact factor: 5.135
Abstract
The normal diurnal variation in plasma corticosterone (COR) was abolished and the response to ether stress was enhanced at 3 days following the production of medial forebrain bundle (MFB) lesions in male rats. However, by 7 days following surgery, basal plasma COR levels and the response to ether stress appeared normal. These alterations and subsequent recovery of pituitary-adrenal activity were accompanied by decreasing hypothalamic synaptosomal uptake of serotonin (5HT) and increasing synaptosomal uptake of dopamine (DA), evident at 3 and continuing at 7 days following the lesion. Uptake of norepinephrine (NE) was not affected at 3 days but showed a reduction at 7 days following surgery. The results suggest that disruption of ascending 5HT and NE fibers to the hypothalamus can alter pituitary-adrenal activity but that normal activity recovers by 7 days following the lesion. The correlation between recovery of pituitary-adrenal activity and increases in the normal uptake of hypothalamic DA suggest that DA may interact with 5HT and NE systems in the normal control of adrenocorticotrophin (ACTH) release.
MeSH terms
Animals; Biogenic Amines; Brain Mapping; Circadian Rhythm; Corticosterone; Dopamine; Hypothalamus; Male; Medial Forebrain Bundle; Neural Pathways; Norepinephrine; Pituitary-Adrenal System; Rats; Serotonin; Synaptosomes
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