Deficiency of alpha1-antitrypsin and bronchiectasis.
Ann Clin Res, 1978/4;10(2):79-82.
Varpela E, Koistinen J, Korhola O, Keskinen H
PMID: 307937
Abstract
60 consecutive patients with bronchiectasis were screened for alpha1-antitrypsin deficiency. Six cases (10%) with genotype PiMZ (alpha1-antitrypsin less than 66% of normal) were found. This frequency (10%) was statistically significantly (p less than 0.005) higher than the frequency of PiMZ (2.7%) in the control group. In two patients the bronchiectasis was cystic. It is suggested that the deficiency states of alpha1-antitrypsin promoting the proteolysis can participate in the genesis of bronchiectasis.
MeSH terms
Adolescent; Adult; Aged; Bronchiectasis; Female; Genotype; Humans; Male; Middle Aged; alpha 1-Antitrypsin Deficiency
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