The effects of acute hypercapnia on cerebral indole amine metabolism.
Can J Physiol Pharmacol, 1978/4;56(2):223-6.
PMID: 305815
Impact factor: 2.245
Abstract
The effects of 1-h exposure to hypercapnia (PaCO2, 90-110 MMHg) on cerebral indole amine metabolism were studied in rats by measurement of cerebral hemisphere contents of tryptophan, 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA), 5-HIAA content was increased after 1-h exposure to hypercapnia, whereas tryptophan, 5-HTP, and 5-HT remained unchanged from control. The accumulation of 5-HTP after decarboxylase inhibition with 3-hydroxybenzyl hydrazine was increased in hypercapnic rats and indicated an increased activity of tryptophan hydroxylase. During the 1-h exposure to hypercapnia there was increased accumulation of 5-HT after monoamine oxidase inhibition with pargyline and increased accumulation of 5-HIAA arter probenecid. The results indicate an increased synthesis and degradation of indole amines in acute hypercapnia.
MeSH terms
5-Hydroxytryptophan; Amines; Animals; Brain; Hydrazines; Hydroxyindoleacetic Acid; Hydroxylation; Hypercapnia; Indoles; Male; Pargyline; Probenecid; Rats; Serotonin; Tryptophan
More resources
EndNote: Download