Reaginic antibody formation in the mouse. X. Possible role of suppressor T cells in transient IgE antibody responses.
J Immunol, 1978/3;120(3):837-43.
PMID: 305447
Impact factor: 5.426
Abstract
The kinetics of IgE antibody response to alum-absorbed dinitrophenyl derivatives of ovalbumin (DNP-OA) was dependent on the dose of immunogen. A persistent IgE antibody response was obtained when high responder BDF1 mice were immunized with a minimum (0.05 microgram) dose. An increase of the immunogen to 10 microgram depressed IgE antibody responses but enhanced IgG antibody responses of both hapten and carrier specificities. Determination of T helper cell activity and B memory cells after immunization with different doses of antigen indicated that minimum immunogen was favorable for developing helper activity, whereas 1 to 10 microgram immunogen were more favorable than a 0.05-microgram dose for developing both IgE and IgG B memory cells. Nevertheless, neither helper T cells nor B memory cells in the spleen explains a transient IgE antibody response to a high (10 microgram) dose of DNP-OA. Evidence was obtained that immunization with 10 microgram OA induced generation of antigen-specific suppressor T cells, which were not detectable after immunization with 0.05 microgram OA. Transfer of suppressor T cells to DNP-OA-primed mice depressed both anti-hapten and anti-carrier IgE antibody responses. The results suggested strongly that suppressor T cells are involved in a transient IgE antibody response to a high-dose immunogen.
MeSH terms
Animals; Antibody Formation; B-Lymphocytes; Dinitrobenzenes; Dose-Response Relationship, Immunologic; Female; Humans; Immunoglobulin E; Immunoglobulin G; Immunosuppression Therapy; Lymphocyte Cooperation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ovalbumin; Reagins; T-Lymphocytes
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