Increase in peripheral blood 'null' cells in extrinsic bronchial asthma.
Clin Exp Immunol, 1977/12;30(3):429-33.
Thomson NC, Sandilands GP, Gray K, Reid F
PMID: 304788
Impact factor: 5.732
Abstract
Lymphocyte subpopulations were measured in the peripheral blood of fifteen patients with extrinsic bronchial asthma and twenty-seven normal control subjects. No significant differences in the absolute numbers of relative proportions of T, B or K lymphocytes were found. Antibody-dependent lymphocyte-mediated cytotoxicity (K-cell activity) was also found to be normal. The proportion and absolute number of 'null' cells were significantly increased in the asthmatic group: this population did not correlate with serum IgE levels, the eosinophil count or the duration of disease. The significance of these results in relation to suppressor T-cell control of IgE formation is discussed.
MeSH terms
Adolescent; Adult; Antibody-Dependent Cell Cytotoxicity; Asthma; B-Lymphocytes; Female; Humans; Killer Cells, Natural; Leukocyte Count; Lymphocytes; Male; Middle Aged; Receptors, Antigen, B-Cell; Rosette Formation; T-Lymphocytes
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