[Advances in studies on steroidal saponins and their pharmacological activities in genus Lilium].
Zhongguo Zhong Yao Za Zhi, 2018/4;43(7):1416-1426.
Luo LM[1, 2], Qin L[1], Pei G[1, 2], Huang SG[1, 2], Zhou XJ[1, 2], Chen NH[1, 2, 3]
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PMID: 29728031DOI: 10.19540/j.cnki.cjcmm.2018.0055
Abstract
Genus Lilium plants contain a variety of steroidal saponins, so far at least 82 steroidal saponins have been found in the bulbs of Lilium species, including 13 spirostanol saponins (1-13), 39 isospirostanol saponins (14-52), 7 pseudospirostanol saponins (53-59), and 23 furostanol saponins (60-82). Studies have showed that these steroidal saponins exhibit a wide range of pharmacological activities, including antitumor, antibacterial, antiinflammatory, antioxidant, antidepressant, hepatoprotective, hypoglycemic, sedative-hypnotic effect, and inhibition of cAMP phosphodiesterase and Na⁺-K⁺ ATP, et al. This paper has classified and summarized the 82 steroidal saponins isolated and identified from the bulbs of Lilium species and their correlative biological activities. Also, their structural characteristics and structure-activities relationship have been discussed, which could provide references for further research and application development of Lilium plants.
Keywords: bulbs ; genus Lilium ; pharmacological activities ; steroidal saponins
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