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25114828
Response to rituximab in a case of lupus associated digital ischemia.

Case Rep Rheumatol, 2014;2014:763608.

Küçükşahin O[1], Düzgün N[1], Okoh AK[2], Kulahçioglu E[2]

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PMID: 25114828DOI: 10.1155/2014/763608

Abstract
We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) and Jaccoud arthritis (JA) that sequentially developed digital ischemic lesions of the hands. In spite of follow-up treatment with glucocorticoids, immunosuppressant, antiaggregant, and potent vasodilatator agents, a serious progression to digital gangrene over a one-month period was observed. Surprisingly, her nonhealing digital lesions improved after two cycles of rituximab (RTX) administration.
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