The amphetamine-induced inhibition of dopamine biosynthesis in rat striatum.
Eur J Pharmacol, 1976/2;35(2):389-92.
PMID: 2484
Impact factor: 5.195
Abstract
The dopamine biosynthetic machinery of intact synaptosomes of rat striatum showed a 5-fold increase in development from 3-day-old neonates to adults, and it was fully developed between 2-3 weeks after birth. Concurring with this development was the appearance 2 weeks after birth of a regulatory mechanism(s) through which amphetamine in vivo induced an inhibition of dopamine biosynthesis. The inhibition was not appreciably reversed when haloperidol, in addition to amphetamine, was administered.
MeSH terms
Aging; Animals; Animals, Newborn; Corpus Striatum; Depression, Chemical; Dextroamphetamine; Dopamine; Haloperidol; Rats; Synaptosomes; Tyrosine 3-Monooxygenase
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