Effect of pKb on lipophilic binding of disopyramide derivatives to human plasma.
J Pharm Sci, 1975/10;64(10):1632-5.
PMID: 241827
Impact factor: 3.784
Abstract
The extent of plasma binding, the partition coefficient, and the pKb of 13 disopyramide derivatives were determined. The structural variation on the diisopropylaminoethyl group of disopyramide molecules influenced these physical parameters to varying degrees. Results demonstrated that the extent of interaction between drugs and human plasma was a linear function of their lipophilicity and inversely proportional to the magnitude of the pKb value.
MeSH terms
Blood Proteins; Disopyramide; Humans; Hydrogen-Ion Concentration; Kinetics; Protein Binding; Pyridines; Structure-Activity Relationship
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