[Pharmacological and radioprotective properties of some gamma-pyrone derivatives (flavanones and flavanols)].
Farmakol Toksikol, 1975/9-1975/10;38(5):607-12.
Il'iuchenok TIu, Khomenko AI, Frigidova LM, Lepekhin VP, Verkhovskiĭ IuG
PMID: 241663
Abstract
In experiments set up on mice, rats and guinea pigs 8 gamma-pyron derivatives were studied. They proved to be little toxic, do not change significantly the arterial pressure and respiration, exercise a depressing action on the central nervous system, produce a marked antiphlogistic (normal and irradiated animals), radio-protective and antihistaminic effects and influence norephinephrine, homovanillic acid and dopamine metabolism in the brain.
MeSH terms
Animals; Anti-Inflammatory Agents; Brain; Catecholamines; Female; Flavonoids; Guinea Pigs; Histamine H1 Antagonists; Lethal Dose 50; Male; Mice; Plant Extracts; Pyrans; Pyrones; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; Siberia; Time Factors; Trees; Wood
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