[Effect of cocarboxylase on hyperlactatemia and hyperpyruvicemia induced by phenformin in dogs].
C R Seances Soc Biol Fil, 1975;169(1):121-5.
Valette G, Ribes G, Rondot AM, Loubatières-Mariani MM, Loubatières AL
PMID: 241466
Abstract
In the normal anesthetized dog, a cocarboxylase perfusion considerably reduced the increase in blood lactate and pyruvate levels provoked by the intraduodenal injection of phenformin (30 mg/kg); furthermore it seems to counteract the increase of the lactates/pyruvates ratio and opposes the fall in blood pH.
MeSH terms
Animals; Blood; Dogs; Hydrogen-Ion Concentration; Lactates; Phenformin; Pyruvates; Thiamine Pyrophosphate
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