The metabolism of N-ethyl-N-methylaniline by rabbit liver microsomes: the measurement of metabolites by gas-liquid chromatography.
Xenobiotica, 1975/8;5(8):453-63.
Gorrod JW, Temple DJ, Beckett AH
PMID: 241155
Impact factor: 1.997
Abstract
1. A method for the determination of N-ethyl-N-methylaniline and its metabolites by g.l.c. is described. 2. Following incubation in N-ethyl-N-methylaniline with rabbit liver microsomes for 60 min, over 95% of the substrate was accounted for as unchanged compound or metabolites. 3. N-Ethyl-N-methylaniline is metabolized in vitro by rabbit tissues mainly by N-oxidation and N-demethylation and to a lesser extent by N-deethylation and di-dealkylation. 4. Both major routes of metabolism were observed in homogenates prepared from rabbit liver and lung; in addition N-oxidation occurred in kidney and bladder tissue homogenates.
MeSH terms
Aniline Compounds; Animals; Chromatography, Gas; Chromatography, Thin Layer; Hot Temperature; Liver; Male; Microsomes, Liver; NADP; Organ Specificity; Oxidoreductases, N-Demethylating; Rabbits; Structure-Activity Relationship; Subcellular Fractions
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