Glutamine synthetase activity in WI-38 cells.
J Cell Physiol, 1975/8;86(1):9-13.
PMID: 240864
Impact factor: 6.513
Abstract
In the presence of complete growth media (Eagle's MEM), human diploid WI-38 cells have a low level of glutamine synthetase activity. The activity could be increased by depriving the cells of exogenous glutamine; addition of hydrocortisone to either glutamine-deficient or complete medium had no effect on the acitivty of the enzyme. Cell growth ceased under conditions that enhanced glutamine synthetase activity, and hydrocortisone could not reverse this inhibition.
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