Subcellular distribution and properties of kynurenine pyruvate transaminase in rat kidney.
Hoppe Seylers Z Physiol Chem, 1975/8;356(8):1245-50.
Noguchi T, Nakatani M, Minatogawa Y, Morimoto M, Kido R
PMID: 240768
Abstract
Kynurenine transaminase activity in rat kidney was found in both the mitochondrial and supernatant fractions. These fractions contained (a) kynurenine pyruvate transaminase, which showed a preference for pyruvate as amino acceptor, and had a pH optimum between 8.0 and 8.5, and (b) kynurenine 2-oxoglutarate transaminase, with a preference for 2-oxoglutarate and a pH optimum between 6.0 and 6.5. The apparent Km value of the former enzyme for L-kynurenine was much lower than that of the latter enzyme.
MeSH terms
Cytosol; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kidney; Kinetics; Kynurenine; Mitochondria, Liver; Pyruvates; Subcellular Fractions; Transaminases
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