A critical study on RO-4-1284 antagonism in mice.
Arch Int Pharmacodyn Ther, 1975/5;215(1):40-90.
Colpaert FC, Lenaerts FM, Niemegeers CJ, Janssen PA
PMID: 240331
Abstract
Ro-4-1284 is found to produce ptosis, hypothermia, sedation and miosis in mice, and the antagonsim to these symptoms is investigated. The study reports the differential effects of various pharmacologically distinct classes of compounds. The relevance of this type of experiments to possible antidepressant drug activity is discussed.
MeSH terms
2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Analgesics; Animals; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Body Temperature; Histamine H1 Antagonists; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase Inhibitors; Motor Activity; Muscle Relaxants, Central; Parasympatholytics; Pupil; Quinolizines; Sympathomimetics; Tranquilizing Agents
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