Pharmacological properties of n1-piperonyl-n4-3,7,11-trimethyl-2,6,10-dodecatrienyl-piperazine, a new non-anticholinergic gastric antisecretory agent.
Arzneimittelforschung, 1975/4;25(4):580-9.
Bianchetti A, Guarneri L, Biraschi LM, Riva M
PMID: 239733
Abstract
The special and general pharmacology of N1-piperonyl-N4-3,7,11-trimethyl-2,6,10-dodecatrienylpiperazine (U-27) is reported. According to the results of the animal experiments the compound turned out to be a well tolerated gastric antisecretory drug devoid of anticholinergic activity. The compound was able to prevent hypersecretion induced by pylorus ligature in rat and guinea pig. Its duration of action was remarkable and no tolerance occurred after a repeated treatment. The compound displayed also an interesting activity on several experimental ulcers.
MeSH terms
Animals; Carbachol; Central Nervous System; Depression, Chemical; Dogs; Feeding Behavior; Female; Gastric Juice; Gastric Mucosa; Gastrointestinal Agents; Gastrointestinal Motility; Guinea Pigs; Hemodynamics; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Male; Methacholine Compounds; Mice; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pentagastrin; Peptic Ulcer; Piperazines; Polyenes; Rabbits; Rats; Respiration
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