[Addition of gentamicine to polymethyl methacrylate for therapy of infectious bone diseases. Expeimental in vivo tests].
Z Orthop Ihre Grenzgeb, 1975/2;113(1):147-9.
Koschmieder R, Ritzerfield W, Homeyer L
PMID: 239496
Abstract
In experimental in vivo tests the therapeutic effect of Gentamicin added to Palacos is detected in a standardized osteomyelitic infection caused by Staph. aureus haemolyticus. The number of germ populations is reduced significantly by the antibiotic which is released in a microbiologically active concentration. On the other hand the number of germ populations in control trials (without adding an antibiotic) is remaining on a high level. During the time of the tests the appearance of other bacterial is registrated.
MeSH terms
Animals; Arthroplasty; Bone Cements; Bone and Bones; Disease Models, Animal; Drug Resistance, Microbial; Escherichia coli; Gentamicins; Methylmethacrylates; Osteomyelitis; Pseudomonas aeruginosa; Staphylococcal Infections; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Surgical Wound Infection; Swine
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