Cyclic AMP and psoriasis.
J Invest Dermatol, 1975/7;65(1):170-8.
Halprin KM, Adachi K, Yoshikawa K, Levine V, Mui MM, Hsia SL
PMID: 239070
Impact factor: 7.59
Abstract
Evidence that an adenyl cyclase system is present in all mammalian epidermis is reviewed. This adenyl cyclase is stimulated by at least two separate types of chemicals: catecholamines, which act at a beta-adrenergic receptor site, and prostaglandins of the E series, which act at a separate site. In the psoriatic lesion, the response to these stimulators, especially to the catecholamines, is reduced. Despite this lack of response to external agents which elevate cyclic AMP, the concentration of cyclic AMP within the epidermis of the psoriatic lesion is no lower than in noninvolved skin. How cyclic nucleotides act to control cell proliferation and cell differentiation remains unclear.
MeSH terms
Adenosine Monophosphate; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Catecholamines; DNA; Guinea Pigs; Humans; Prostaglandins; Psoriasis; Rats; Skin
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