Comparison of behaviors elicited by electrical brain stimulation in dorsal brain stem and hypothalamus of rats.
J Comp Physiol Psychol, 1975/2;88(2):816-28.
Ellman SJ, Ackermann RF, Bodnar RJ, Jackler F, Steiner SS
PMID: 239032
Abstract
Four brain-stimulation phenomena elicited from both dorsal brain stem and hypothalamic sites were investigated with the following results: (a) intracranial self-stimulation rate-intensity functions for dorsal brain stem and hypothalamic sites yielded very high (over 1,000 responses/15 min.) to moderate (201-500 responses/15 min.) response rates; (b) d-amphetamine produced higher response rates than either l-amphetamine or saline at both dorsal brain stem and hypothalamic sites, indicating that noradrenergic dorsal brain stem fibers (or cell bodies) support intracranial self-stimulation; (c) dorsal brain stem and hypothalamic self-stimulation sites reliably produced escape behavior; (d) simultaneous stimulation of dorsal brain stem and hypothalamic sites at subthreshold intensities interacted to produce suprathreshold response rates.
MeSH terms
Adrenergic alpha-Agonists; Amphetamine; Animals; Arousal; Brain Stem; Chemoreceptor Cells; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Electrophysiology; Escape Reaction; Hypothalamus; Injections, Intraperitoneal; Isomerism; Male; Rats; Reaction Time; Seizures; Self Stimulation
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