Attempted immunologic reconstitution of patients with combined immune deficiency syndrome with bone marrow transplantation from histoincompatible donors.
Birth Defects Orig Artic Ser, 1975;11(1):417-20.
Parkman R, Gelfand EW, Rosen FS
PMID: 238685
Abstract
The immunologic reconstitution from patients with combined immune deficiency syndrome was attempted with bone marrow transplantation from histoincompatible donors. None of the patients achieved long-term immunologic reconstitution. In all cases, the incompatible bone marrow was treated before transplantation. Physical separation of the stem and immunocompetent cells was attempted in 2 cases with the use of enhancing antibody in one of the attempts. The selective destruction of the immunocompetent bone marrow cells after specific stimulation was attempted in the last 2 cases.
MeSH terms
Antibody-Producing Cells; Bone Marrow Cells; Bone Marrow Transplantation; Bromodeoxyuridine; Cell Separation; Genotype; Graft vs Host Reaction; Hematopoietic Stem Cells; Histocompatibility; Immunologic Deficiency Syndromes; Pedigree; Thymidine; Transplantation, Homologous; Tritium
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