On the presence of a MSH-release inhibiting system in the rat neurointermediate lobe.
Neuroendocrinology, 1975;18(1):125-30.
Tilders FJ, Mulder AH, Smelik PG
PMID: 238163
Impact factor: 5.135
Abstract
Rat neurointermediate lobes were superfused in vitro and showed a stable secretion rate of MSH after 30 min. MSH secretion from lobes of untreated rats was reversibly inhibited during superfusion with medium containing 45 mM K+. This inhibition could not be induced using lobes from median eminence lesioned or reserpinized rats. Superfusion with 45 mM K+ also induced release of dopamine from lobes preincubated with the labeled transmitter. It is concluded that the MSH-release inhibiting system present in the rat neurointermediate lobe may be identical to the dopaminergic arcuate-intermediate lobe system.
MeSH terms
Animals; Biological Assay; Diabetes Insipidus; Dopamine; Female; Hypothalamus; MSH Release-Inhibiting Hormone; Median Eminence; Perfusion; Pituitary Gland; Potassium; Rats; Reserpine; Time Factors
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