Amino acid composition of proteins: Selection against the genetic code.
Science, 1975/7/04;189(4196):50-1.
Jukes TH, Holmquist R, Moise H
PMID: 237322
Impact factor: 63.714
Abstract
Distribution of amino acids in 68 representative proteins is compared with their distribution among 61 codons of the genetic code. Average amounts of lysine, aspartic acid, glutamic acid, and alanine are above the levels anticipated from the genetic code, and arginine, serine, leucine, cysteine, proline, and histidine are below such levels. Arginine plus lysine account for 11.0 percent of codons and aspartic acid plus glutamic acid account for 11.3 percent; thus the average charge is roughly neutral.
MeSH terms
Amino Acid Sequence; Amino Acids; Biological Evolution; Codon; Genetic Code; Hydrogen-Ion Concentration; Mutation; Protein Biosynthesis; Proteins; RNA, Messenger
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