Generation of prostaglandin E-like material by the guinea-pig trachea contracted by histamine.
J Pharm Pharmacol, 1975/2;27(2):88-91.
Grodzinska L, Panczenko B, Gryglewski RJ
PMID: 237082
Impact factor: 4.81
Abstract
Challenges of the superfused (1 ml min-1) trachea with histamine (100-200 mug) result in the release of prostaglandin E-like material (3-25 ng in terms of prostaglandin E2) but no prostaglandin F-like activity has been detected in the superfusate. This release is blocked by indomethacin (1mug ml-1) and then the contractile action of histamine is enhanced. It is concluded that the release of a prostaglandin E-like material by histamine from tracheal smooth muscles is a self-defensive mechanism protecting against the strong constriction of airways. The maximal relaxation of trachea by isoprenaline (50-500 mug) is not accompanied by the release of a prostaglandin-like material.
MeSH terms
Animals; Colon; Histamine; In Vitro Techniques; Indomethacin; Isoproterenol; Mice; Muscle Contraction; Muscle, Smooth; Prostaglandins; Rats; Stomach; Trachea
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