Induction of T-cells differentiation in vitro by thymus epithelial cells.
Ann N Y Acad Sci, 1975/2/28;249:492-8.
Waksal SD, Cohen IR, Waksal HW, Wekerle H, St Pierre RL, Feldman M
PMID: 236721
Impact factor: 6.499
Abstract
Thymus-reticular epithelial cells (TE-cells) were grown in a cell culture devoid of any lymphocytic elements. These cells were able to induce T-cell differentiation in spleen cells from T-dificient mice as expressed by con-A responsiveness and GvH reactivity. It was also shown that xenogeneic rat TE cells were as effective in the induction of T-cell differentiation in vitro as syngeneic TE cells. This system is therefore ideal for the study of T-cell development.
MeSH terms
Animals; Cell Differentiation; Cells, Cultured; Concanavalin A; DNA; Epithelial Cells; Epithelium; Female; Graft vs Host Reaction; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microscopy, Electron; Radiation Chimera; Rats; Rats, Inbred Lew; Species Specificity; Spleen; T-Lymphocytes; Thymectomy; Thymidine; Thymus Gland; Transplantation, Homologous; Tritium
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