Postmortem changes in brain catecholamine enzymes.
Arch Neurol, 1975/1;32(1):47-9.
PMID: 234734
Abstract
Postmortem changes in the activities of tyrosine hydroxylase, dopa decarboxylase, and dopamine-beta-hydroxylase were examined in various areas of rat brain. Tyrosine hydroxylase activity decreased in an exponential fashion with a half-time of two to four hours in caudate-putamen, substantia nigra, and locus ceruleus. Dopa decarboxylase activity remained within 20% of control values at five hours in these areas, but then decreased precipitously. Dopamine-beta-hydroxylase activity remained within 20% of control for at least 20 hours after death.
MeSH terms
Animals; Brain; Caudate Nucleus; Cerebral Ventricles; Dopa Decarboxylase; Dopamine beta-Hydroxylase; Female; Male; Postmortem Changes; Putamen; Rats; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase
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