Immunologic induction of malignant lymphoma: identification of donor and host tumors in the graft-versus-host model.
J Natl Cancer Inst, 1975/1;54(1):107-16.
Gleichmann E, Gleichmann H, Schwartz RS, Weinblatt A, Armstrong YK
PMID: 234534
Impact factor: 11.816
Abstract
Primary lymphoid tumors were induced by inoculation of parental line spleen cells into H-2 incompatible F1 hybrid mice. The genotypes of lymphomas arising in 19 different parent yields F1 combinations were determined with cytotoxic antisera against H-2 specificities of donor and host. Additional chromosome marker studies established the reliability of tumor genotyping by the cytotoxicity test. According to H-2 typing, 12 primary lymphomas were of donor type, 66 of host type, and 14 of intermediate type. As a group, those parent yields F1 combinations in which donor-type lymphomas developed (group 1) showed a higher degree of histocompatibility between donor and host than those combinations in which donor-type lymphomas failed to appear (group 2). Allogeneic inhibition may have suppressed the development of donor-type tumors in the combinations of group 2. The development of malignant lymphomas of donor-type in the graft-versus-host reaction (GNHR) supports the concept of lymphomagenesis as a consequence of persistent stimulation by antigen.
MeSH terms
Animals; Cytotoxicity Tests, Immunologic; Genotype; Graft vs Host Reaction; Histocompatibility Antigens; Histocompatibility Testing; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Neoplasm Transplantation; Sex Chromosomes; Spleen; Transplantation, Homologous
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