Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.
J Exp Med, 1977/3/01;145(3):644-51.
Affiliations
PMID: 233908
Impact factor: 17.579
Abstract
Virus-immune cytotoxic T cells can inhibit effectively growth of vaccinia virus in acutely infected target cells in vitro by destroying infected target cells before infectious virus progeny is assembled. Together with the fact that virus-specific T cells are demonstrable after 3 days, very early during infection, and with strong circumstantial evidence from adoptive transfer models in vivo, these data suggest that in some virus infections T cells may in fact act cytolytically in vivo to prevent virus growth and spread and be an important early antiviral effector mechanism.
MeSH terms
Animals; Fibrosarcoma; Kinetics; Mice; Mice, Inbred BALB C; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Vaccinia; Vaccinia virus; Virus Replication
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