Evidence for a role of alpha-adrenergic mechanisms in regulation of episodic growth hormone secretion in the rat.
Endocrinology, 1977/3;100(3):722-8.
Durand D[1], Martin JB, Brazeau P
Affiliations
PMID: 233821
Impact factor: 5.051
Abstract
The role of catecholamines in regulation of episodic GH secretion was investigated in the male rat. Administration of alpha-methyl-p-tyrosine (alpha-MT; 250 mg/kg ip) caused significant suppression of GH bursts and resulted in marked elevation of plasma PRL. Intravenous administration of apomorphine (.03 and .1 mg/kg) had no effect on decreased GH levels, whereas clonidine (150 micrograms/kg) restored GH secretion. Apomorphine significantly reduced PRL levels in alpha-MT-treated rats whereas, clonidine resulted in a further increase in PRL.
MeSH terms
Animals; Apomorphine; Clonidine; Growth Hormone; Male; Methyltyrosines; Periodicity; Prolactin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha
More resources
EndNote: Download