Mechanism of beta-adrenergic relaxation of smooth muscle.
Nature, 1979/1/04;277(5691):32-6.
Scheid CR, Honeyman TW, Fay FS
PMID: 233257
Impact factor: 69.504
Abstract
The mechanism of beta-adrenergic relaxation was investigated in isolated smooth muscle cells. Beta-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.
MeSH terms
Animals; Biological Transport, Active; Bufo marinus; Calcium; Cyclic AMP; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium; Protein Kinases; Receptors, Adrenergic; Receptors, Adrenergic, beta; Sodium; Sodium-Potassium-Exchanging ATPase
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