Dopamine-mediated behavior produced by the enkephalin analogue FK 33-824.
Psychiatry Res, 1979/12;1(3):333-9.
Extein I, Lo C, Goodwin FK, Schoenfeld RI
PMID: 233159
Impact factor: 11.225
Abstract
Intraperitoneal injection of FK 33-824 produced apomorphine-like stereotyped behavior in rats. Antagonism of this stereotypy by naloxone and neuroleptics suggests that FK 33-824 can activate opiate and dopamine receptors in the brain. Because increased dopaminergic neuronal activity is thought to be involved in schizophrenia and dopamine-mediated stereotypy has been used as an animal model for this illness, these results are consistent with an involvement of endogenous opiate-like peptides in schizophrenia. This involvement provides a possible mechanism for the reported improvement in schizophrenic psychosis produced by naloxone.
MeSH terms
Animals; Apomorphine; Chlorpromazine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Haloperidol; Humans; Male; Naloxone; Rats; Receptors, Dopamine; Receptors, Opioid; Stereotyped Behavior
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