9, 11-Azo-12-oxa-15-hydroxyprostanoic acid: a potent thromboxane synthetase inhibitor and a PGH2/TxA2 receptor antagonist.
Prostaglandins Med, 1979/11;3(5):279-90.
PMID: 233035
Abstract
9,11-Azo-13-oxa-15-hydroxyprostanoic acid (AOHP) is shown to be a potent inhibitor of thromboxane synthetase with an IC50 at about 10(-6)M. It also blocked the agonist actions of 9,11-epoxymethano-PGH2 (IC50 9 x 10(-7) M) and TxA2 (IC50 2.4 x 10(-6) M) on human platelet-rich plasma indicating that it also is a PGH2/TxA2 receptor blocker.
MeSH terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Humans; Microsomes; Oxidoreductases; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, Prostaglandin; Swine; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes
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