Electroneurographic investigations of misonidazole polyneuropathy.
Eur Neurol, 1979;18(6):405-14.
Mamoli B, Wessely P, Kogelnik HD, Müller M, Rathkolb O
PMID: 232682
Impact factor: 2.292
Abstract
13 patients with malignant tumors were treated by the radiosensitizer misonidazole (Ro 07-0582), total dosage 20-29 g. The electrophysiological investigations showed (1) an early increase of distal latency, the motor nerve conduction velocity (NCV) of the peroneal nerve and the NCV of the sural nerve remaining normal or only signlty reduced, and in a few cases a marked reduction of the compound action potential or of the nerve action potential (NAP), indicating a primary axonal neuropathy; (2) greater changes in the parameters of sensory nerves (n. suralis) than of motor nerves; (3) the distal latency is a good indicator of subclinical neuropathies; (4) the electrophysiological parameters showed a normalization 6 months after the end of therapy. The mechanisms possibly responsible for the misonidazole neuropathy are discussed.
MeSH terms
Action Potentials; Adult; Aged; Female; Humans; Male; Middle Aged; Misonidazole; Motor Neurons; Neoplasms; Nerve Fibers; Neural Conduction; Nitroimidazoles; Peripheral Nerves; Peripheral Nervous System Diseases; Peroneal Nerve; Sural Nerve; Time Factors
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