[On the pathogenesis of isocyanate-induced asthma].
Respiration, 1979;38(5):289-98.
PMID: 231808
Impact factor: 3.966
Abstract
3 asthmatic patients, occupationally exposed to vapors of toluylene diisocyanate (TDI), responded with a moderate to strong elevation of airway resistance up to the 26th h after inhalation challenge by 0.006--0.02 ppm TDI. No changes in chest radiographs and in DLCO were found. In none of the patients' sera, isocyanate-specific antibodies could be detected by RAST and Ouchterlony test. Change of job resulted in one case in an immediate interruption of the asthmatic symptoms, whereas in 2 patients recovery was slow over a period of 3 to 8 months and not complete. Our investigations suggest a toxic effect of isocyanates, which depends on their concentrations, and an important pharmacological reaction; but, up to now, there were no signs of allergic mechanisms.
MeSH terms
Adult; Asthma; Cyanates; Humans; Middle Aged; Occupational Diseases; Radioallergosorbent Test; Respiratory Function Tests; Toluene 2,4-Diisocyanate
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