Kainate neurotoxicity and glutamate inactivation.
Neurosci Lett, 1979/10;14(2-3):343-8.
Lodge D, Johnston GA, Curtis DR, Bornstein JC
PMID: 231233
Impact factor: 3.197
Abstract
Dihydrokainate, an inhibitor of high affinity L-glutamate as an excitant of cat spinal neurones in vivo. This action of dihydrokainate was selective in that the effects of excitants taken up actively in vitro by CNS tissue (L-aspartate, D- and L-glutamate and L-homocysteate) were enhanced whereas those of other substances not taken up (acetylcholine, D-homocysteate, kainate and N-methyl-D-aspartate) were not. Since kainate and dihydrokainate have similar potencies as inhibitors of L-glutamate uptake, interference with the inactivation of synaptically released L-glutamate may contribute to the neurotoxic effects of kainate.
MeSH terms
Amino Acids; Animals; Cats; Drug Interactions; Excitatory Amino Acid Antagonists; Interneurons; Kainic Acid; Pyrrolidines; Receptors, Neurotransmitter; Spinal Cord
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