High-affinity binding of [3H]muscimol to subcellular particles of a neurone-enriched culture of embryonic rat brain.
Neurosci Lett, 1979/10;14(2-3):195-9.
DeFeudis FV, Ossola L, Schmitt G, Mandel P
PMID: 231232
Impact factor: 3.197
Abstract
High-affinity, Na+-independent binding of [3H]muscimol (KB approximately equal to 1.6 x 10(-8) M; Bmax approximately equal to 0.14 nmol/g pellet) occurred to a frozen-thawed particulate fraction of 74-h-old neurone-enriched cultures prepared from the cerebra of 12-13-day-old rat embryos. This finding provides evidence that GABA-receptors exist on cultured neurones which contain only a few synaptic connections.
MeSH terms
Animals; Brain; Brain Chemistry; Culture Techniques; Muscimol; Oxazoles; Rats; Receptors, Neurotransmitter; Subcellular Fractions; gamma-Aminobutyric Acid
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