Parallel investigations of the effects of adenosine on evoked potentials and cyclic AMP accumulation in hippocampus slices of the rat.
Neurosci Lett, 1979/9;14(1):37-42.
PMID: 231229
Impact factor: 3.197
Abstract
In slices of rat hippocampus, adenosine and its receptor agonist, 2-chloro-adenosine, were both found to (a) enhance the intracellular accumulation of cyclic adenosine monophosphate (cAMP) and (b) depress neuronal evoked responses to electrical stimulation. The differences in the dose/effect curves for the biochemical and electrophysiological changes cast doubt on a causal relationship between the two effects.
MeSH terms
Adenosine; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; In Vitro Techniques; Rats
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