Loss of beta-adrenoceptor binding sites in rat striatum following kainic acid lesions.
Eur J Pharmacol, 1979/12/07;60(2-3):249-52.
Nahorski SR, Howlett DR, Redgrave P
PMID: 230980
Impact factor: 5.195
Abstract
Intrastriatal injection of kainic acid (5 nmoles) to rats led to severe destruction of nerve cell bodies throughout the caudate-putamen complex and an extensive proliferation of glial cells. Lesioned striata displayed a significant 23% loss of beta-adrenoceptor binding sites 21--24 days after injection of kainic acid. Further analysis of these changes revealed that this loss of sites was selectively within the beta 1 receptor population. Although these results do not rule out a partial glial cell localisation for beta-adrenoceptors, they do indicate that at least a proportion of beta 1 receptors are present on striatal perikarya.
MeSH terms
Animals; Axons; Corpus Striatum; Dihydroalprenolol; Isoproterenol; Kainic Acid; Male; Pyrrolidines; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta
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