Selective immunodeficiency and malignant lymphoma of the central nervous system. Possible relationship to the Epstein-Barr virus.
Acta Neuropathol, 1979/12;48(3):165-9.
Pattengale PK, Taylor CR, Panke T, Tatter D, McCormick RA, Rawlinson DG, Davis RL
PMID: 230688
Impact factor: 15.887
Abstract
This report presents the findings of a study of a 17-year-old male with a selective immunodeficiency to the Epstein-Barr virus, who died of a malignant lymphoma following clinical infectious mononucleosis. Autopsy findings and immunohistochemical techniques demonstrated a malignant lymphoma with B-lymphocyte characteristics which primarily involved the central nervous system (CNS). The relationship of the Epstein-Barr virus to lymphoproliferation is discussed.
MeSH terms
Adolescent; Antibodies, Viral; B-Lymphocytes; Central Nervous System Diseases; Herpesvirus 4, Human; Humans; Immunologic Deficiency Syndromes; Infectious Mononucleosis; Lymphoma; Male
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