(3,4-Dihydroxybenzyl)-2-imidazoline (DHBI): an analogue of dopamine.
Res Commun Chem Pathol Pharmacol, 1979/11;26(2):243-51.
O'Donnell JP, Azzaro AJ, Urquilla PR
PMID: 230552
Abstract
(3,4-Dihydroxybenzyl)-2-imidazoline (DHBI) was prepared and evaluated for dopamine receptor activity by studying its relaxant effects in the rabbit isolated renal and ear arteries and by measuring its ability to enhance dopamine sensitive adenylate cyclase in the rat striatum. DHBI relaxed both the rabbit isolated renal and ear arteries in the presence of phenoxybenzamine (2. 9 X 10(-5)M) and propranolol (3.4 X 10(-7) M) while dopamine and the specific renal dopamine agonist 6,7-dihydroxy-2-aminotetrahydronaphthalene (6,7-ADTN) demonstrated a ratio of specificity for the renal versus the less responsive ear artery. DHBI did not cause a typical increase in adenylate cyclase activity, however DHBI did attenuate the stimulatory a
MeSH terms
Adenylyl Cyclases; Animals; Arteries; Catechols; Corpus Striatum; Cyclic AMP; Imidazoles; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrites; Rabbits; Rats; Receptors, Dopamine; Renal Artery
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