Some effects of an ACTH 4-9 analog (Org 2766) on human performance.
Physiol Behav, 1979/7;23(1):79-84.
PMID: 229501
Impact factor: 3.742
Abstract
The effects (on human beings) of the ACTH analog Org 2766 were investigated for a range of performance tests: complicated serial reaction task, running memory span, verbal learning and non-verbal mental ability tests (closure flexibility and non-verbal abstraction). Subjective ratings on feelings were taken and heart rate was measured. Only the 30-min reaction task produced significant drug effects. In this task performance tends to deteriorate as a function of time on task. During the test period there is a gradual increase in the number of lapses in performance due to moments of inattention. This deterioration is counteracted by the ACTH 4-9 analog, a result also found in previous study using ACTH 4-10 (Org OI63). Thus ACTH fragments which are devoid of endocrine effects seem to have a beneficial effect on goal-directed motivation oriented on the requirements of the task.
MeSH terms
Adrenocorticotropic Hormone; Emotions; Female; Heart Rate; Humans; Male; Memory; Motivation; Psychological Tests; Reaction Time; Time Factors; Verbal Learning
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