Regional distribution of a high-affinity enkephalin-degrading peptidase ('enkephalinase') and effects of lesions suggest localization in the vicinity of opiate receptors in brain.
Neurosci Lett, 1979/3;11(3):329-34.
Malfroy B, Swerts JP, Llorens C, Schwartz JC
PMID: 229439
Impact factor: 3.197
Abstract
The distribution of a high affinity enkephalin-dipeptidylcarboxypeptidase between regions of mouse brain is markedly heterogenous and parallels that of opiate receptors. Furthermore intrastriatal administration of kainic acid as well as interruption of the nigrostriatal dopaminergic pathway by 6-hydroxydopamine (6-OHDA) lead to similar decreases in this peptidase activity and in the number of opiate receptors. On the contrary, no correlation was found between low affinity enkephalin degrading enzymes and opiate receptors.
MeSH terms
Animals; Brain; Brain Chemistry; Brain Stem; Cerebellum; Cerebral Cortex; Corpus Striatum; Endopeptidases; Enkephalins; Hippocampus; Hypothalamus; Kainic Acid; Mice; Receptors, Opioid
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